Journal: Therapeutic Advances in Medical Oncology
Article Title: Mismatch repair protein imbalance in head and neck squamous cell carcinoma: associations with clinical features and survival
doi: 10.1177/17588359251408596
Figure Lengend Snippet: Correlation between MMR protein expression and immune cell subsets in HNSCC. (a–f) Correlation of MSH2, MSH6, PMS2, MLH1, MSH2/MSH6, and PMS2/MLH1 ratios with immune cell subsets. (g) Diagram of correlation patterns among MMR proteins. (h) Correlation between MSH2 expression and CD8+ T cells in nontumor tissues. (i) Correlation between MSH6 expression and CD4+ T cells in tumor tissues. (j) Correlation between PMS2/MLH1 ratio expression and CD4+ T-cell in tumor tissues. HNSCC, head and neck squamous cell carcinoma; MMR, mismatch repair.
Article Snippet: Briefly, MSH2 (ZSGB-BIO ® ; ZA-0622, 1:2000), MSH6 (Roche Diagnostics GmbH ® ; SP93, ready-to-use), PMS2 (Dako ® ; EP51, ready-to-use), MLH1 (Dako ® ; ES05, ready-to-use), CD4 (Abcam; ab133616, 1:2000), CD8 (SinoBiological; 10980-R081, 1:500), and Foxp3 (Abcam; ab191416, 1:1000) antibodies were used to immunohistochemically stain the TMA slides, with brown staining considered as positive immunoreaction and blue staining considered as negative immunoreaction (nuclear, cytoplasm, or membrane, based on cells of interest).
Techniques: Expressing